A Family Based Study Implicates Solute Carrier Family 1–Member 3 (SLC1A3) Gene in Attention-Deficit/Hyperactivity Disorder

@article{Turic2005AFB,
  title={A Family Based Study Implicates Solute Carrier Family 1–Member 3 (SLC1A3) Gene in Attention-Deficit/Hyperactivity Disorder},
  author={Darko Turic and Kate Langley and Hywel J. Williams and Nadine Norton and Nigel Melvillle Williams and Valentina Moskvina and Marianne van den Bree and Michael J. Owen and Anita Thapar and Michael C. O’Donovan},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={1461-1466}
}
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TLDR
Considering that several trends for association are observed, studies using larger samples are required to determine whether these genes are associated with TS or ADHD, and none of the genotyped markers remained significant following corrections for multiple testing.
Association study for genes at chromosome 5p13‐q11 in attention deficit hyperactivity disorder
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  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
The results suggest that these six genes are unlikely to be susceptibility genes in the chromosome 5p13‐q11 region and other genes should now be considered for priority study.
A functional variant in SLC1A3 influences ADHD risk by disrupting a hsa‐miR‐3171 binding site: A two‐stage association study
TLDR
SLC1A3 variant rs1049522 was implicated in ADHD susceptibility in a Chinese Han population probably by enhancing the SLC1 a3 expression in a miRNA‐mediated manner.
Association of the glutamate receptor subunit gene GRIN2B with attention‐deficit/hyperactivity disorder
TLDR
The data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
TLDR
A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases, and rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts were identified.
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TLDR
It is concluded that dopamine and serotonin releasers might be useful therapeutic adjuncts for the treatment of other RDS behavioral subtypes, including addictions.
Brain imaging genetics in ADHD and beyond – Mapping pathways from gene to disorder at different levels of complexity
DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics
TLDR
Future strategies for genetic studies in ADHD are discussed, highlighting both the pitfalls and possible solutions relating to candidate gene studies, genome-wide studies, defining the phenotype, and statistical approaches.
Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region
  • N. Laurin, K. Wigg, Yu Feng, P. Sandor, C. Barr
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
TLDR
This study represents the first efforts to narrow the linkage region in the extended pedigree and the first tests of candidate genes in the chromosome 5 region linked to TS.
From gene to disorder in ADHD: Mapping mechanisms at different levels of complexity
TLDR
Among other findings, it is able to show that ADHD and the intracranial volume are significantly negatively correlated at the global genetic level, resembling earlier phenotypic observations.
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References

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TLDR
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TLDR
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TLDR
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