A Family Based Study Implicates Solute Carrier Family 1–Member 3 (SLC1A3) Gene in Attention-Deficit/Hyperactivity Disorder

@article{Turic2005AFB,
  title={A Family Based Study Implicates Solute Carrier Family 1–Member 3 (SLC1A3) Gene in Attention-Deficit/Hyperactivity Disorder},
  author={Darko Turic and Kate Langley and Hywel J. Williams and Nadine Norton and Nigel Melvillle Williams and Valentina Moskvina and Marianne van den Bree and Michael J. Owen and Anita Thapar and Michael C. O’Donovan},
  journal={Biological Psychiatry},
  year={2005},
  volume={57},
  pages={1461-1466}
}
A Genetic Association Study of Glutamate Transporter Genes SLC1A1 and SLC1A3 in Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder
TLDR
Considering that several trends for association are observed, studies using larger samples are required to determine whether these genes are associated with TS or ADHD, and none of the genotyped markers remained significant following corrections for multiple testing.
Association study for genes at chromosome 5p13‐q11 in attention deficit hyperactivity disorder
  • N. Laurin, Jonghun Lee, C. Barr
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
The results suggest that these six genes are unlikely to be susceptibility genes in the chromosome 5p13‐q11 region and other genes should now be considered for priority study.
A functional variant in SLC1A3 influences ADHD risk by disrupting a hsa‐miR‐3171 binding site: A two‐stage association study
TLDR
SLC1A3 variant rs1049522 was implicated in ADHD susceptibility in a Chinese Han population probably by enhancing the SLC1 a3 expression in a miRNA‐mediated manner.
Association of the glutamate receptor subunit gene GRIN2B with attention‐deficit/hyperactivity disorder
TLDR
The data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
TLDR
A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases, and rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts were identified.
Attention-deficit-hyperactivity disorder and reward deficiency syndrome
TLDR
It is concluded that dopamine and serotonin releasers might be useful therapeutic adjuncts for the treatment of other RDS behavioral subtypes, including addictions.
DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics
TLDR
Future strategies for genetic studies in ADHD are discussed, highlighting both the pitfalls and possible solutions relating to candidate gene studies, genome-wide studies, defining the phenotype, and statistical approaches.
Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region
  • N. Laurin, K. Wigg, Yu Feng, P. Sandor, C. Barr
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2009
TLDR
This study represents the first efforts to narrow the linkage region in the extended pedigree and the first tests of candidate genes in the chromosome 5 region linked to TS.
From gene to disorder in ADHD: Mapping mechanisms at different levels of complexity
TLDR
Among other findings, it is able to show that ADHD and the intracranial volume are significantly negatively correlated at the global genetic level, resembling earlier phenotypic observations.
...
1
2
3
...

References

SHOWING 1-10 OF 49 REFERENCES
Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region
TLDR
Owing to the role of GRIN2A in aspects of cognition, the relationship of this gene to the cognitive phenotypes of inhibitory control, verbal short-term memory and verbal working memory was investigated and there was no significant evidence of linkage between GRin2A and these phenotypes.
Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD
TLDR
The data suggest that genetic variation in GRIN2A may confer increased risk for ADHD and that this, at least in part, might be responsible for the linkage result on 16p reported by Smalley et al.
Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11.
TLDR
The concordance between results from different analytical methods of linkage and the replication of data between two independent studies suggest that these loci truly harbor ADHD susceptibility genes.
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
TLDR
Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia, and reconstructed the genomic structure of all five genes encoding NMDA receptors in silico, finding a further 26 polymorphisms within exonic or adjacent intronic sequences suitable for studying neuropsychiatric phenotypes.
Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11.
TLDR
Fine mapping of nine positional candidate regions for attention-deficit/hyperactivity disorder (ADHD) in an extended population sample of 308 affected sibling pairs (ASPs), constituting the largest linkage sample of families with ADHD published to date, indicates that four chromosomal regions--5p13, 6q12, 16 p13, and 17p11--are likely to harbor susceptibility genes for ADHD.
Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes.
TLDR
Genotypic information from 14 independent samples of probands and their parents and joint analysis showed association with the DRD5 locus, and this association appears to be confined to the predominantly inattentive and combined clinical subtypes.
A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11.
TLDR
Two regions are suggested as highly likely to harbor risk genes for ADHD: 16p13 and 17p11, Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism.
A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
TLDR
This is the first systematic genomewide linkage scan for loci influencing ADHD in 126 affected sib pairs, using a approximately 10-cM grid of microsatellite markers and indicates that there is unlikely to be a major gene involved in ADHD susceptibility in this sample.
Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder.
TLDR
Although the association between ADHD and DRD4 is small, these results suggest that it is real and further studies are needed to clarify what variant ofDRD4 accounts for this association.
Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis
TLDR
The meta-analyses support the involvement of the dopamine system genes in ADHD liability variation and suggest the need for studies examining interactions between these genes.
...
1
2
3
4
5
...