A Facile and Efficient One‐Pot Synthesis of Dihydropyrimidinones Catalyzed by Magnesium Bromide Under Solvent‐Free Conditions

  title={A Facile and Efficient One‐Pot Synthesis of Dihydropyrimidinones Catalyzed by Magnesium Bromide Under Solvent‐Free Conditions},
  author={Hojatollah Salehi and Qingxiang Guo},
  journal={Synthetic Communications},
  pages={171 - 179}
Abstract Magnesium bromide efficiently catalyzes the three‐component condensation reaction of aldehyde, β‐diketon and urea/thiourea under solvent‐free conditions to afford the corresponding dihydropyrimidinones in high yields and short reaction time. 
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Biologically important 12 new important 3,4-dihydropyrimidin-2-(1H)-ones (-thiones) were synthesized with in one-pot three-component Biginelli reaction from the corresponding aromatic aldehydes
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Abstract An efficient synthesis of 3,4‐dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β‐ketoester, and urea in acetonitrile is described.
Bismuth triflate catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2 (1H)-ones: An improved protocol for the Biginelli reaction
An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth triflate as the catalyst for the first time from an aldehyde, β-keto ester and urea in acetonitrile is described. Compared to
Magnesium Bromide Catalysed Acylation of Alcohols
Abstract Magnesium bromide is an efficient catalyst for the acetylation and benzoylation of a variety of primary and secondary alcohols with the respective acid anhydrides at ambient temperature.
Simple and regioselective synthesis of N-substituted pyrimidine-2(1H)-ones and -thiones
The di-imines (1), obtained by the reaction of Schiff bases with saturated nitriles, react with ethyl chloroformate and carbon disulphide giving rise to an efficient method for synthesising
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Diastereoselective direct aldol reactions of chiral N-acylthiazolidinethiones occur in high yield with preference for the illustrated anti diastereomer in the presence of triethylamine and chlorotrimethylsilane.