A Facile Regioselective 1,3-dipolar Cycloaddition Protocol for the Synthesis of Thiophene containing Spiro Heterocycles
@inproceedings{Kanagaraju2014AFR, title={A Facile Regioselective 1,3-dipolar Cycloaddition Protocol for the Synthesis of Thiophene containing Spiro Heterocycles}, author={Geethanjali Kanagaraju and A. Thangamani}, year={2014} }
An efficient three component synthesis of novel spiropyrrolidine compounds were obtained in good-to-excellent yields from the chemo-regio-and stereoselective reaction between �,�-unsaturated ketones with thiophene substituents and non-stabilized azomethineylides, generated in situ from acenaphthenequinone and sarcosine. This protocol has the advantages of highly efficiency, mild reaction conditions, a one-pot procedure, easy workup, short reaction times, convenient operation, and catalyst-free… CONTINUE READING
References
SHOWING 1-10 OF 52 REFERENCES
Ultrasound-promoted regioselective and stereoselective synthesis of novel spiroindanedionepyrrolizidines by multicomponent 1,3-dipolar cycloaddition of azomethine ylides
- Chemistry
- Research on Chemical Intermediates
- 2012
- 12
1,3-Dipolar cycloaddition of arynes with azomethine imines: synthesis of 1,2-dihydropyrazolo[1,2-a]indazol-3(9H)-ones.
- Chemistry, Medicine
- Tetrahedron letters
- 2009
- 51
Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide.
- Chemistry, Medicine
- European journal of medicinal chemistry
- 2010
- 104
Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids
- Chemistry
- 2003
- 997