Corpus ID: 98384914

A Facile One-Pot Process for Hindered Tertiary Amine Formation

@inproceedings{Pei2008AFO,
  title={A Facile One-Pot Process for Hindered Tertiary Amine Formation},
  author={D. Pei and Y. Zhang and J. Sun},
  year={2008}
}
Tertiary amine is a key structural motif in numerous biologically active natural products. Direct reductive amination (DRA) of carbonyls with amine is one of the most convenient and straightforward methods for the synthesis of amines. It proceeds in a one-pot fashion under mild conditions and is compatible with many functional groups. While DRA has been widely used as a highly effective method for the preparation of primary and secondary amines, the applications of such protocol for the… Expand