A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic.

@article{Cormont2001AFP,
  title={A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic.},
  author={Mireille Cormont and Montse Mari and Antoine Galmiche and Paul F Hofman and Yannick Le Marchand-Brustel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 4},
  pages={1637-42}
}
The small GTPase Rab4 is implicated in endocytosis in all cell types, but also plays a specific role in some regulated processes. To better understand the role of Rab4 in regulation of vesicular trafficking, we searched for an effector(s) that specifically recognizes its GTP-bound form. We cloned a ubiquitous 69-kDa protein, Rabip4, that behaves as a Rab4 effector in the yeast two-hybrid system and in the mammalian cell. Rabip4 contains two coiled-coil domains and a FYVE-finger domain. When… CONTINUE READING

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