A FRET-based assay for the discovery of West Nile Virus NS2B-NS3 protease inhibitors.

Abstract

The West Nile Virus (WNV) has been a worldwide epidemic since the early 1990s. Currently there are no therapeutic treatments for WNV infections. One particular avenue of treatment is inhibition of the NS2B-NS3 protease, an enzyme that is crucial for WNV replication. In our effort to increase the number of NS2B-NS3 protease inhibitors, we report a novel FRET… (More)
DOI: 10.1016/j.bmcl.2013.06.081

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@article{Adamek2013AFA, title={A FRET-based assay for the discovery of West Nile Virus NS2B-NS3 protease inhibitors.}, author={Rebecca N Adamek and Roxanne V Maniquis and Sabaha Khakoo and Michael D. Bridges and Nicholas T Salzameda}, journal={Bioorganic & medicinal chemistry letters}, year={2013}, volume={23 17}, pages={4848-50} }