A FISH approach to defining the extent and possible clinical significance of deletions at the WAGR locus.

@article{Crolla1997AFA,
  title={A FISH approach to defining the extent and possible clinical significance of deletions at the WAGR locus.},
  author={John Anthony Crolla and J E Cawdery and Christine A. Oley and Ian D. Young and Joe Gray and Judith A Fantes and Veronica van Heyningen},
  journal={Journal of medical genetics},
  year={1997},
  volume={34 3},
  pages={207-12}
}
Nineteen patients were analysed by fluorescence in situ hybridisation (FISH) with selected 11p13 markers. They were examined because they had either isolated sporadic or familial aniridia, or aniridia with one or more of the WAGR (Wilms' tumour, aniridia, genital anomalies, and mental retardation) syndrome anomalies. The FISH markers from distal 11p13 were cosmids FO2121, PAX6 (aniridia), D11S324, and WT1 (Wilms' tumour predisposition). Two of the patients with isolated aniridia were abnormal… CONTINUE READING

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