A Ewing's sarcoma cell line showing some, but not all, of the traits of a cholinergic neuron.

@article{ORegan1995AES,
  title={A Ewing's sarcoma cell line showing some, but not all, of the traits of a cholinergic neuron.},
  author={Seana O'Regan and Marie Françoise Diebler and F. M. Meunier and Subhash Vyas},
  journal={Journal of neurochemistry},
  year={1995},
  volume={64 1},
  pages={69-76}
}
The Ewing's sarcoma cell line ICB 112 was examined in detail for a cholinergic phenotype. Choline acetyltransferase activity (12.3 +/- 2.9 nmol/h/mg of protein) was associated with the presence of multiple mRNA species labeled with a human choline acetyltransferase riboprobe. Choline was taken up by the cells by a high-affinity, hemicholinium-3-sensitive transporter that was partially inhibited when lithium replaced sodium in the incubation medium; the choline taken up was quickly incorporated… CONTINUE READING
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