A Dynamical Model Reveals Gene Co-Localizations in Nucleus

  title={A Dynamical Model Reveals Gene Co-Localizations in Nucleus},
  author={Jing Kang and Bing Xu and Ye Yao and Wei Lin and Conor Hennessy and Peter Fraser and Jianfeng Feng},
  journal={PLoS Computational Biology},
Co-localization of networks of genes in the nucleus is thought to play an important role in determining gene expression patterns. Based upon experimental data, we built a dynamical model to test whether pure diffusion could account for the observed co-localization of genes within a defined subnuclear region. A simple standard Brownian motion model in two and three dimensions shows that preferential co-localization is possible for co-regulated genes without any direct interaction, and suggests… 

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