A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-Sensing Ion Channel 1

@inproceedings{Saez2011ADP,
  title={A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-Sensing Ion Channel 1},
  author={Natalie J. Saez and Mehdi Mobli and Michael Bieri and Ir{\`e}ne R. Chassagnon and Alpeshkumar K. Malde and Roland Gamsjaeger and Alan E. Mark and Paul R. Gooley and Lachlan D Rash and Glenn F. King},
  year={2011}
}
Acid-sensing ion channel 1a (ASIC1a) is a primary acid sensor in the peripheral and central nervous system. It has been implicated as a novel therapeutic target for a broad range of pathophysiological conditions including pain, ischemic stroke, depression, and autoimmune diseases such as multiple sclerosis. The only known selective blocker of ASIC1a is -TRTXPc1a (PcTx1), a disulfide-rich 40-residue peptide isolated from spider venom. -TRTX-Pc1a is an effective analgesic in rodent models of… CONTINUE READING