A Dynamic Network Approach for the Study of Human Phenotypes

  title={A Dynamic Network Approach for the Study of Human Phenotypes},
  author={R. A. Hidalgo CesarA.Hidalgo and Nicholas Blumm and Albert-L{\'a}szl{\'o} Barab{\'a}si and Nicholas A. Christakis},
  journal={PLoS Computational Biology},
  pages={8685 - 8690}
The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database summarizing correlations obtained from the disease history of more than 30 million patients in a Phenotypic Disease Network (PDN). We present evidence that the structure of the PDN is relevant to the understanding of illness progression by showing that (1) patients develop… CONTINUE READING
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