A Dual-Purpose Protein Ligand for Effective Therapy and Sensitive Diagnosis of Anthrax

@article{Vuyisich2008ADP,
  title={A Dual-Purpose Protein Ligand for Effective Therapy and Sensitive Diagnosis of Anthrax},
  author={Momchilo Vuyisich and Sandrasegaram Gnanakaran and Julie A. Lovchik and C. Rick Lyons and Gautam Gupta},
  journal={The Protein Journal},
  year={2008},
  volume={27},
  pages={292-302}
}
This article reports the design of a bivalent protein ligand with dual use in therapy and diagnosis of anthrax caused by Bacillus anthracis. The ligand specifically binds to PA and thereby blocks the intracellular delivery of LF and EF toxins that, respectively, cause cell lysis and edema. The ligand is a chimeric scaffold with two PA-binding domains (called VWA) linked to an IgG-Fc frame. Molecular modeling and binding measurements reveal that the VWA-Fc dimer binds to PA with high affinity… CONTINUE READING

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