A Dual‐Functional Persistently Luminescent Nanocomposite Enables Engineering of Mesenchymal Stem Cells for Homing and Gene Therapy of Glioblastoma

@article{Wu2017ADP,
  title={A Dual‐Functional Persistently Luminescent Nanocomposite Enables Engineering of Mesenchymal Stem Cells for Homing and Gene Therapy of Glioblastoma},
  author={Shuna Wu and Cheng‐Xiong Yang and Xiu‐Ping Yan},
  journal={Advanced Functional Materials},
  year={2017},
  volume={27}
}
Therapeutically engineered mesenchymal stem cells (MSC) have shown promising capability for glioblastoma (GBM) therapy; however, simultaneous tracking of their migration and long‐term fate is urgently needed for clinical application. This study shows the design and fabrication of a dual‐functional persistent luminescence nanocomposite (LPLNP‐PPT/TRAIL) for effective therapeutic engineering and tracking of MSC in the meantime. LPLNP‐PPT/TRAIL shows low‐toxicity, near‐infrared persistent… 
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