A Drosophila model for alcohol reward

  title={A Drosophila model for alcohol reward},
  author={K. R. Kaun and Reza Azanchi and Zin Thu Zar Maung and James Hirsh and Ulrike A Heberlein},
  booktitle={Nature Neuroscience},
The rewarding properties of drugs contribute to the development of abuse and addiction. We developed a new assay for investigating the motivational properties of ethanol in the genetically tractable model Drosophila melanogaster. Flies learned to associate cues with ethanol intoxication and, although transiently aversive, the experience led to a long-lasting attraction for the ethanol-paired cue, implying that intoxication is rewarding. Temporally blocking transmission in dopaminergic neurons… CONTINUE READING
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