A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients

@inproceedings{Wesenbeeck2015ADT,
  title={A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients},
  author={Liesbeth Van Wesenbeeck and Karin Vandermeiren and Jeroen Tolboom and Hanne Meeuws and Dominic Edmund Dwyer and Mark W. Holmes and Michael G Ison and Kevin Katz and Allison Mcgeer and Jerald C. Sadoff and Gerrit Jan Weverling and Lieven J Stuyver},
  booktitle={Open forum infectious diseases},
  year={2015}
}
Background.  Efficacy endpoints in influenza clinical trials may include clinical symptoms and virological measurements, although virology cannot serve as the primary endpoint. We investigated the relationship between influenza A RNA copy number and quantity of infectious viruses in hospitalized influenza patients. Methods.  One hundred fifty influenza-infected, hospitalized patients were included in this prospective cohort study spanning the 2012-2013 influenza season. Daily nasopharyngeal… CONTINUE READING

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