A Double Edged Sword: MAD2 Dependent Mitotic Checkpoint Defects in Tumorigenesis and Tumor Cell Death

@inproceedings{Michel2004ADE,
  title={A Double Edged Sword: MAD2 Dependent Mitotic Checkpoint Defects in Tumorigenesis and Tumor Cell Death},
  author={Loren Scott Michel and Robert Benezra and Esther Diaz-Rodriguez},
  year={2004}
}
The failure of cell cycle regulatory checkpoints is a common event in human cancer. Defects at the G1-S transition have been widely characterized, but only more recently has aberrant checkpoint signaling during mitotic progression been identified as playing a role in cancer. The metaphase to anaphase transition is regulated by multiple proteins that together comprise the mitotic checkpoint. Previously it has been shown that loss of one copy of MAD2, a mitotic checkpoint gene, results in… CONTINUE READING

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