A Double Blind Comparison of Venlafaxine and Paroxetine in Obsessive-Compulsive Disorder

@article{Denys2003ADB,
  title={A Double Blind Comparison of Venlafaxine and Paroxetine in Obsessive-Compulsive Disorder},
  author={Damiaan A.J.P. Denys and Nic J.A. van der Wee and Harold J. G. M. van Megen and Herman G. M. Westenberg},
  journal={Journal of Clinical Psychopharmacology},
  year={2003},
  volume={23},
  pages={568-575}
}
While the usefulness of clomipramine and selective serotonin reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) has been established, the efficacy of serotonin-norepinephrine reuptake inhibitors remains to be determined. This report describes the first randomized double-blind comparison study of an SNRI in patients with obsessive-compulsive disorder. The current study compares the efficacy and tolerability of venlafaxine with paroxetine. One hundred and fifty patients with… 
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References

SHOWING 1-10 OF 33 REFERENCES
Paroxetine versus Clomipramine in the Treatment of Obsessive–Compulsive Disorder
TLDR
Paroxetine is as effective as clomipramine in the treatment of OCD and the comparable efficacy and better tolerability of parxetine suggest that it would be an appropriate treatment for OCD.
A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder.
TLDR
Fluoxetine was associated with a statistically significant reduction in OCD severity, including time engaged in obsessional and/or compulsive behaviors, and greater efficacy at 60 mg/d was observed.
Treatment of obsessive—compulsive disorder with fluvoxamine: a multicentre, double‐blind, placebo‐controlled trial
TLDR
Fluvoxamine was significantly more effective than placebo as assessed by the Yale Brown Obsessive-Compulsive Scale (Y-BOCS), the National Institute of Mental Health Obsessives Compulsive (NIMH-OC) scale and (be Global Improvement item of the Clinical Global Impression (CGI) scale).
Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder.
TLDR
Results support the safety and efficacy of daily dosages of 50, 100, and 200 mg of sertraline in the short-term treatment of patients with OCD.
Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis.
TLDR
While the results of this meta-analysis support the superiority of clomipramine, head-to-head, double-blind comparisons of these compounds would be the best test of comparative efficacy and tolerability.
Clomipramine in the treatment of patients with obsessive-compulsive disorder. The Clomipramine Collaborative Study Group.
TLDR
Clomipramine was generally well tolerated and was effective in reducing obsessive and compulsive symptoms and was superior on the basis of the physicians' and patients' evaluations of global therapeutic change.
Venlafaxine in obsessive-compulsive disorder.
In a contribution to the January 1995 issue of the Archives comparing the efficacy and tolerability of clomipramine, fluoxetine, fluvoxamine, and sertraline, Greist et al, 1 using a method of
Citalopram 20 mg, 40 mg and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder
TLDR
This first trial to assess the efficacy of the most selective of the serotonin reuptake inhibitors, citalopram, in OCD found all three doses were significantly more effective than placebo measured on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) change score.
Meta‐analysis of pharmacotherapy trials for obsessive‐compulsive disorder
TLDR
This study supports previous work suggesting that increased serotonergic specificity is not necessarily correlated with greater efficacy in the treatment of OCD, and suggests that serotonin reuptake inhibitor (SRI) type had a significant effect on medication effect size.
A 1 year double‐blind placebo‐controlled fixed dose study of sertraline in the treatment of obsessive‐compulsive disorder
TLDR
Results support the safety, efficacy and tolerability of daily doses of 50–200 mg of sertraline in the long-term treatment of patients with OCD.
...
...