A Double‐Blind Study of Lorazepam versus the Combination of Haloperidol and Lorazepam in Managing Agitation

  title={A Double‐Blind Study of Lorazepam versus the Combination of Haloperidol and Lorazepam in Managing Agitation},
  author={St. Bieniek and Raymond L. Ownby and Alberto Pe{\~n}alver and Roberto A. Dominguez},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Study Objective. To compare the utility of intramuscular lorazepam (LZ) with the combination of intramuscular haloperidol (HDL) and LZ to control acutely agitated behavior. 

A naturalistic comparison study of the efficacy and safety of intramuscular olanzapine, intramuscular haloperidol, and intramuscular levomepromazine in acute agitated patients with schizophrenia

This study was a comparative investigation of the clinical efficacy and safety of intramuscular (IM) olanzapine, IM haloperidol, and IM levomepromazine in acute agitated patients with schizophrenia.

Comparison of Intranasal Administration of Haloperidol with Intravenous and Intramuscular Administration: A Pilot Pharmacokinetic Study

Study Objective. To evaluate the pharmacokinetics of haloperidol after intranasal administration compared with intravenous and intramuscular administration, and to evaluate systemic and local

Effects of Intramuscular Midazolam and Lorazepam on Acute Agitation in Non-Elderly Subjects - A Systematic Review.

There is no doubt that benzodiazepines are less likely to be associated with treatment emergent side effects, as compared to antipsychotics, and randomized trials evaluating intramuscular (IM) midazolam or lorazepam given as monotherapy or as add-on treatment, with more than 10 patients aged 18-65 years, conducted in a psychiatric setting were included.

A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients.

Midazolam has a significantly shorter time to onset of sedation and a more rapid time to arousal than lorazepam or haloperidol, and the efficacies of all three drugs appear to be similar.

Are Low Doses of Antipsychotics Effective in the Management of Psychomotor Agitation? A Randomized, Rated-Blind Trial of 4 Intramuscular Interventions

Low doses of haloperidol combined with midazolam can be as effective as olanzapine in reducing psychomotor agitation without increasing the risk of extrapyramidal effects.

Treatment of Agitation With Lorazepam in Clinical Practice: A Systematic Review

Based on this structured review, lorazepam can be considered to be a clinically effective means of treating the acutely agitated patient.

Intramuscular Olanzapine in the Management of Acute Agitation

Additional studies comparing intramuscular olanzapine with combination antipsychotic/benzodiazepine therapy in more severely ill patients and patients with concomitant medical illnesses are needed to determine the most effective dosing regimen, use of adjunctive medications, and to obtain a comprehensive safety profile.

Inhaled loxapine and intramuscular lorazepam in healthy volunteers: a randomized placebo‐controlled drug–drug interaction study

Although the central nervous system sedative effects were observed for each treatment in healthy volunteers, the effect was greater following concomitant lorazepam 1 mg IM + inhaled loxapine 10 mg administration.

Evidence-Based Review of Pharmacotherapy for Acute Agitation. Part 1: Onset of Efficacy.

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Data support the current clinical practice of using lorazepam (alone, or in combination with a neuroleptic) for control of acute aggressive and assaultive behavior.

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The combination of haloperidol, 5 mg, and lorazepam, 4 mg, was both effective and safe for managing agitated behavior in an open trial with acutely psychotic patients. The combination also appeared

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Lorazepam may offer an efficacious and safe alternative to haloperidol as an adjunctive treatment to lithium in the clinical management of the early phase of manic agitation in a subgroup of bipolar patients.

Rapid Tranquillisation

Diazepam alone or in combination with haloperidol delivered intravenously was most rapidly effective and was associated with greatest staff satisfaction, and serious side-effects were rare.

The Overt Aggression Scale for the objective rating of verbal and physical aggression.

The authors describe the design and reliability of a rating scale that measures aggressive behaviors in adults and children and the clinical and research applications of this scale are discussed.

Handbook on Injectable Drugs

In the 16th Edition, all the monographs are updated, with 349 parenteral drugs commercially available in the United States and elsewhere in alphabetical order by nonproprietary name, including brand names for absolute usefulness and clarity.

The inexact use of Fisher's Exact Test in six major medical journals.

The use of Fisher's Exact Test without specification as a one- or two-tailed version may misrepresent the statistical significance of data and a uniform specification statement should be required for all manuscripts to correct potential errors in interpretation.

A power primer.

  • J. Cohen
  • Mathematics
    Psychological bulletin
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A convenient, although not comprehensive, presentation of required sample sizes is providedHere the sample sizes necessary for .80 power to detect effects at these levels are tabled for eight standard statistical tests.