A Double‐Blind Study of Lorazepam versus the Combination of Haloperidol and Lorazepam in Managing Agitation

@article{Bieniek1998ADS,
  title={A Double‐Blind Study of Lorazepam versus the Combination of Haloperidol and Lorazepam in Managing Agitation},
  author={St. Bieniek and Raymond L. Ownby and Alberto Pe{\~n}alver and Roberto A. Dominguez},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={1998},
  volume={18}
}
Study Objective. To compare the utility of intramuscular lorazepam (LZ) with the combination of intramuscular haloperidol (HDL) and LZ to control acutely agitated behavior. 

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A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients.

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Low doses of haloperidol combined with midazolam can be as effective as olanzapine in reducing psychomotor agitation without increasing the risk of extrapyramidal effects.

Treatment of Agitation With Lorazepam in Clinical Practice: A Systematic Review

Based on this structured review, lorazepam can be considered to be a clinically effective means of treating the acutely agitated patient.

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Additional studies comparing intramuscular olanzapine with combination antipsychotic/benzodiazepine therapy in more severely ill patients and patients with concomitant medical illnesses are needed to determine the most effective dosing regimen, use of adjunctive medications, and to obtain a comprehensive safety profile.

Inhaled loxapine and intramuscular lorazepam in healthy volunteers: a randomized placebo‐controlled drug–drug interaction study

Although the central nervous system sedative effects were observed for each treatment in healthy volunteers, the effect was greater following concomitant lorazepam 1 mg IM + inhaled loxapine 10 mg administration.

Evidence-Based Review of Pharmacotherapy for Acute Agitation. Part 1: Onset of Efficacy.

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