A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain

@inproceedings{Tong2015ADS,
  title={A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain},
  author={Cheuk Ka Tong and Luis Claros Fuentealba and Jugal K. Shah and Robert A. Lindquist and Rebecca A Ihrie and Cristina D. Guinto and Jose L. Rodas-Rodriguez and Arturo Alvarez-Buylla},
  booktitle={Stem cell reports},
  year={2015}
}
Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells… CONTINUE READING
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