A Doppler effect in embryonic pattern formation

@article{Soroldoni2014ADE,
  title={A Doppler effect in embryonic pattern formation},
  author={Daniele Soroldoni and David J J{\"o}rg and Luis G. Morelli and David L. Richmond and Johannes E. Schindelin and Frank J{\"u}licher and Andrew C. Oates},
  journal={Science},
  year={2014},
  volume={345},
  pages={222 - 225}
}
Observing an embryonic Doppler effect The sound of an oncoming train changes as it passes you, a phenomenon termed the Doppler effect. Soroldoni et al. propose a similar event during the formation of vertebrate embryo body segments. It is generally thought that the internal timing of a genetic oscillator called the “segmentation clock” sets the rhythm of body segments called somites. However, time-lapse microscopy of the spatial waves of oscillations and the timing of body segment formation… Expand
Cell-autonomous generation of the wave pattern within the vertebrate segmentation clock
TLDR
This work proposes the segmentation clock integrates an intrinsic, timer-driven oscillatory program, which underlies the waves and arrest, with extrinsic cues regulating the intrinsic timer’s duration and precision. Expand
Segmentation clock dynamics is strongly synchronized in the forming somite.
  • R. Bhavna
  • Medicine, Biology
  • Developmental biology
  • 2019
TLDR
From the experimentally determined phases of PSM cellular oscillators, an in vivo frequency profile gradient is deduced along the anterior-posterior PSM axis and precise mathematical relations between spatial cell-level period and tissue-level somitogenesis period are inferred. Expand
Sequential pattern formation governed by signaling gradients.
TLDR
It is shown that a set of coupled genetic oscillators in an elongating tissue that is regulated by diffusing and advected signaling molecules can account for segmentation as a self-organized patterning process. Expand
Faster embryonic segmentation through elevated Delta-Notch signalling
TLDR
The results reveal surprising differences in how Notch signalling strength is quantitatively interpreted in different organ systems, and suggest a role for intercellular communication in regulating the output period of the segmentation clock by altering its spatial pattern. Expand
From local resynchronization to global pattern recovery in the zebrafish segmentation clock
Rhythmic spatial gene expression patterns termed the segmentation clock regulate vertebrate body axis segmentation during embryogenesis. The integrity of these patterns requires local synchronizationExpand
Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity
TLDR
Real-time imaging of clock gene oscillations in zebrafish embryos reveals that the segmentation clock shifts from one- to two-segment periodicity, suggesting an updated model for somite formation. Expand
Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
TLDR
This approach provides an experimental and conceptual framework for direct manipulation of the segmentation clock with unprecedented single-cell resolution, allowing its cell-autonomous and tissue-level properties to be distinguished and dissected. Expand
What are you synching about? Emerging complexity of notch signaling in the segmentation clock.
TLDR
Evidence and models concerning the role of Notch signaling in driving, maintaining and synchronizing the mouse clock are examined, and results emerging from ex vivo culture systems of mouse segmentation clock cells reveal exciting new avenues for investigation into the coordination and precision of patterning the early embryo. Expand
From local resynchronization to global pattern recovery in the zebrafish segmentation clock
TLDR
Stability of rhythmic spatial gene expression patterns in the vertebrate segmentation clock requires local synchronization between neighboring cells by Delta-Notch signaling and its inhibition causes defective segment boundaries, so segmental pattern recovery occurs at two length and time scales. Expand
Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock
TLDR
This work reveals a population of cells from the zebrafish segmentation clock that behave as self-sustained, autonomous oscillators with distinctive noisy dynamics. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 60 REFERENCES
Delayed coupling theory of vertebrate segmentation
TLDR
The delayed coupling theory can be used to analyze experimental perturbations, thereby identifying roles of genes involved in segmentation and revealing the quantitative values of parameters controlling spatial and temporal organization of the oscillators in the system. Expand
A clock and wavefront model for control of the number of repeated structures during animal morphogenesis.
TLDR
It is argued that the elements, a smooth oscillator, a slow wavefront and a rapid cellular change, have biological plausibility and are compatible with experimental observations such as the sequential formation of somites from anterior to posterior in a regular time sequence, the timing of cellular change during development generally, and the increasing evidence for widespread existence of cellular biorhythms. Expand
Scaling of embryonic patterning based on phase-gradient encoding
TLDR
It is shown that scaling of gene oscillation dynamics underlies segment scaling, and the slope of this phase gradient is identified as a single predictive parameter for segment size, revealing a hitherto unrecognized mechanism for scaling. Expand
Synchrony Dynamics During Initiation, Failure, and Rescue of the Segmentation Clock
TLDR
It is concluded that synchrony among these genetic oscillators can be established by simultaneous initiation and self-organization and that the segmentation defect position is determined by the difference between coupling strength and noise. Expand
Setting the Tempo in Development: An Investigation of the Zebrafish Somite Clock Mechanism
TLDR
It is deduced that although her7 continues to oscillate in the anterior half of the PSM, it governs the future somite segmentation behaviour of the cells only while they are in the posterior half, which strongly support the mathematical model of how the somite clock works. Expand
A β-catenin gradient links the clock and wavefront systems in mouse embryo segmentation
TLDR
It is shown that the Wnt-signalling gradient is established through a nuclear β-catenin protein gradient in the posterior PSM, which defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process. Expand
The clock and wavefront model revisited.
TLDR
An alternative formulation of the clock and wavefront model in which oscillator coupling plays a fundamentally important role in the slowing of oscillations along the anterior-posterior (AP) axis is presented, consistent with the idea that, although the genes involved in pattern propagation in the PSM vary, there is a conserved patterning mechanism across species. Expand
Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock
TLDR
This work has provided evidence of how the period of the segmentation clock is regulated and how this affects the anatomy of the embryo. Expand
Dynamics of zebrafish somitogenesis
TLDR
It is shown that somitogenesis period changes more than threefold across the standard developmental temperature range, whereas the axial somite length distribution is temperature invariant, indicating that the temperature‐induced change in somitogenic period exactly compensates for altered axial growth. Expand
Formation and segmentation of the vertebrate body axis.
TLDR
The developmental mechanism of segmentation and the regulation of body length and segment numbers are described and illustrated by discussing findings in other major embryonic model systems, such as mice, frogs, and zebrafish. Expand
...
1
2
3
4
5
...