A Dopamine-Modulated Neural Circuit Regulating Aversive Taste Memory in Drosophila

@article{Masek2015ADN,
  title={A Dopamine-Modulated Neural Circuit Regulating Aversive Taste Memory in Drosophila},
  author={Pavel Masek and Kurtresha Worden and Yoshinori Aso and Gerald M. Rubin and Alex C Keene},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={1535-1541}
}
Taste memories allow animals to modulate feeding behavior in accordance with past experience and avoid the consumption of potentially harmful food [1]. We have developed a single-fly taste memory assay to functionally interrogate the neural circuitry encoding taste memories [2]. Here, we screen a collection of Split-GAL4 lines that label small populations of neurons associated with the fly memory center-the mushroom bodies (MBs) [3]. Genetic silencing of PPL1 dopamine neurons disrupts… CONTINUE READING
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