A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*

@article{Somwar2002ADP,
  title={A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation*},
  author={R. Somwar and Sandra L Koterski and G. Sweeney and R. Sciotti and S. Djuric and C. Berg and J. Trevillyan and P. Scherer and C. M. Rondinone and A. Klip},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={50386 - 50395}
}
  • R. Somwar, Sandra L Koterski, +7 authors A. Klip
  • Published 2002
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Participation of p38 mitogen-activated protein kinase (p38) in insulin-induced glucose uptake was suggested using pyridinylimidazole p38 inhibitors (e.g. SB203580). However, the role of p38 in insulin action remains controversial. We further test p38 participation in glucose uptake using a dominant-negative p38 mutant and two novel pharmacological p38 inhibitors related to but different from SB203580. We present the structures and activities of the azaazulene pharmacophores A291077 and A304000… CONTINUE READING
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