A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q

@article{Kang2006ADC,
  title={A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q},
  author={Yeow Beng Kang and Yoonkyung Do and Hae-Kyung Lee and Sung Ho Park and Cheolho Cheong and R Lynch and Jutta M. Loeffler and Ralph Marvin Steinman and Chae Gyu Park},
  journal={Cell},
  year={2006},
  volume={125},
  pages={47-58}
}
The intricate system of serum complement proteins provides resistance to infection. A pivotal step in the complement pathway is the assembly of a C3 convertase, which digests the C3 complement component to form microbial binding C3 fragments recognized by leukocytes. The spleen and C3 provide resistance against blood-borne S. pneumoniae infection. To better understand the mechanisms involved, we studied SIGN-R1, a lectin that captures microbial polysaccharides in spleen. Surprisingly… CONTINUE READING
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