A Distinct Region in Erythropoietin that Induces Immuno/Inflammatory Modulation and Tissue Protection

@article{Yuan2015ADR,
  title={A Distinct Region in Erythropoietin that Induces Immuno/Inflammatory Modulation and Tissue Protection},
  author={Ruirong Yuan and Bo Wang and Wei Lu and Yasuhiro Maeda and Peter J. Dowling},
  journal={Neurotherapeutics},
  year={2015},
  volume={12},
  pages={850-861}
}
Beneficial effects of short-term whole-molecule erythropoietin (EPO) therapy have been demonstrated on several animal models of diverse central nervous system pathology. However, the increased hematocrit induced by EPO-driven marrow stimulation greatly limits its potential for side effect-free therapy. We created a library of EPO-derived fragments based on the hypothesis that 2 distinct functions, erythropoiesis and tissue protection, reside in different regions of the molecule. Several small… CONTINUE READING