A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

  title={A Distinct Nuclear Import Pathway Used by Ribosomal Proteins},
  author={Michael P. Rout and G{\"u}nter Blobel and John D. Aitchison},
Protein transport into the nucleus is governed by the interaction of soluble transport factors with their import substrates and nuclear pore complexes. Here, we identify a major distinct nuclear import pathway, mediated by a previously uncharacterized yeast beta karyopherin Kap123p. The predominant substrates for this pathway are ribosomal proteins, which must be imported into the nucleus prior to assembly into pre-ribosomes. Kap123p binds directly to its transport substrates, repeat motif… CONTINUE READING
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