A Distinct Mitochondrial Genome with DUI-Like Inheritance in the Ocean Quahog Arctica islandica

  title={A Distinct Mitochondrial Genome with DUI-Like Inheritance in the Ocean Quahog Arctica islandica},
  author={Cyril D{\'e}gletagne and Doris Abele and Christoph Held},
  journal={Molecular Biology and Evolution},
  pages={375 - 383}
Mitochondrial DNA (mtDNA) is strictly maternally inherited in metazoans. The major exception to this rule has been found in many bivalve species which allow the presence of different sex-linked mtDNA molecules. This mechanism, named doubly uniparental inheritance (DUI), is characterized by the presence of two mtDNAs: The female mtDNA is found in somatic tissue and female gonads, whereas the male mtDNA is usually found in male gonads and sperm. In this study we highlight the existence of two… 

Figures and Tables from this paper

Doubly uniparental inheritance and highly divergent mitochondrial genomes of the freshwater mussel Unio tumidus (Bivalvia: Unionidae)

The patterns of polymorphisms across the mitogenomes of the closest relatives confirmed that the M genomes accumulate more substitutions and the conserved regions within one lineage are also conserved in the other.

Gender-Associated Mitochondrial DNA Heteroplasmy in Somatic Tissues of the Endangered Freshwater Mussel Unio crassus (Bivalvia: Unionidae): Implications for Sex Identification and Phylogeographical Studies.

The present study is the first report on gender-associated mitochondrial DNA heteroplasmy in male somatic tissues of thick-shelled river mussel and first approach to U. crassus sex identification at molecular level and confirmed the utility of paternally inherited Mcox1 gene fragment as a complementary molecular tool for resolving phylogeographical relationships among populations of Thick-Shelled River mussel.

Putative sex-linked heteroplasmy in the tellinid bivalve Limecola balthica (Linnaeus, 1758)

Testing for the presence of DUI in Limecola balthica is of prime interest for understanding how this feature spread within the Bivalvia and how many times it evolved.

No evidence of sex-linked heteroplasmy or doubly-uniparental inheritance of mtDNA in five gastropod species

One of the leading hypotheses to explain the origin and maintenance of this unusual mtDNA transmission system in bivalves is that the F and M mtDNAs are key elements of the sex determination system, as heteromorphic sex chromosomes are absent in this taxon.

Presence of male mitochondria in somatic tissues and their functional importance at the whole animal level in the marine bivalve Arctica islandica

This mitochondrial pattern in A. islandica is a special case of DUI, highlighted in individuals from both sexes with functional consequences at cellular and conceivably whole animal level and some individuals in an Icelandic population present homoplasmic presence of male-type mitochondrial genes in somatic tissues, which appears to confer some changes in respiratory capacity in some environmental conditions.

Cytogenetics in Arctica islandica (Bivalvia, Arctidae): the Longest Lived Non-Colonial Metazoan

The knowledge of the karyotype can facilitate the anchoring of genomic sequences to specific chromosome pairs in this species.

No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy

In heteroplasmic individuals, both mitogenomes were present in the generative tissues of both sexes, which argues against the presence of doubly uniparental inheritance in this species.

Evaluating the Utility of Five Gene Fragments for Genetic Diversity Analyses of Mytella strigata Populations

It is indicated that COI is the most useful gene fragment for genetic diversity studies of M. strigata populations; D1 28S and 18S-ITS1 sequences would be useful for species identification because of their low intraspecific diversity.

Molluscan mitochondrial genomes break the rules

This work reviews the extraordinary variation in architecture, molecular functioning and intergenerational transmission of molluscan mitochondrial genomes, and finds many cases where these features do not exist.



The Mitochondrial Genome of Arctica islandica; Phylogeny and Variation

This analysis lays the foundation for further studies on A. islandica population structures, age research with this organism, and for phylogenetic studies.


Observations do not support the hypothesis that DUI originated because it permits the evolution of mitochondrial adaptations specific to sperm performance, otherwise, the evolutionarily older, standard M genome should perform better.

An unusual case of gender-associated mitochondrial DNA heteroplasmy: the mytilid Musculista senhousia (Mollusca Bivalvia)

The inverted variability pattern (the F being more variable than M) was new and it challenges most of the rationales proposed to account for sex-linked mtDNA evolution, suggesting mechanisms evolved to protect mtDNA in females might be under relaxed selection in males.

Strict sex-specific mtDNA segregation in the germ line of the DUI species Venerupis philippinarum (Bivalvia: Veneridae).

It is proposed that the mtDNA transmission is achieved through a three-checkpoint process in V. philippinarum, believing that Checkpoint #3 is a mere variation of the "mitochondrial bottleneck" in species with standard maternal inheritance, established when their PGCs separate during embryo cleavage.

Male and female mitochondrial DNA lineages in the blue mussel (Mytilus edulis) species group.

Maximum parsimony and neighbor-joining phylogenies grouped female and male mtDNAs into two distinct lineages irrespective of specific origin in accordance with the hypothesis that the origin of these lineages predates the divergence of M. edulis and M. trossulus.

Molecular evolution and recombination in gender-associated mitochondrial DNAs of the Manila clam Tapes philippinarum.

The data suggest that recombinants, although occurring in soma, may seldom be transmitted to progeny in T. philippinarum and that selection may act with varying strength on different genes.

Mitochondrial phylogenomics of the Bivalvia (Mollusca): searching for the origin and mitogenomic correlates of doubly uniparental inheritance of mtDNA

The basal nature of the Unionoida within the autolamellibranch bivalve bivalves and the previously hypothesized single origin of DUI suggest that DUI arose in the ancestral autlamelliberation bivalving lineage and was subsequently lost in multiple descendant lineages and the mitochondrial genome characteristics observed in unionoids could more closely resemble the DUI ancestral condition.

Heteroplasmy in a deep-sea protobranch bivalve suggests an ancient origin of doubly uniparental inheritance of mitochondria in Bivalvia

Evidence of mitochondrial heteroplasmy in deep-sea protobranch bivalves is presented and it is suggested that DUI might have evolved much earlier in the evolution of the Bivalvia than previously thought.

The complete maternal and paternal mitochondrial genomes of the Mediterranean mussel Mytilus galloprovincialis: implications for the doubly uniparental inheritance mode of mtDNA.

The maternal (F) and paternal (M) mitochondrial genomes of the mussel Mytilus galloprovincialis have diverged by about 20% in nucleotide sequence but retained identical gene content and gene