A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration

@inproceedings{Grillo2018ADD,
  title={A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration},
  author={F. W. Grillo and Guilherme Neves and Alison S Walker and Gema Vizcay-Barrena and Roland A. Fleck and Tiago Branco and Juan Burrone},
  booktitle={Neuron},
  year={2018}
}
How presynaptic inputs and neurotransmitter release dynamics are distributed along a dendritic tree is not well established. Here, we show that presynaptic boutons that form onto basal dendrites of CA1 pyramidal neurons display a decrease in active zone (AZ) size with distance from the soma, resulting in a distance-dependent increase in short-term facilitation. Our findings suggest that the spatial distribution of short-term facilitation serves to compensate for the electrotonic attenuation of… CONTINUE READING
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