A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

@article{Desai2016ADF,
  title={A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility},
  author={Mahesh S. Desai and Anna M Seekatz and Nicole M Koropatkin and Nobuhiko Kamada and Christina A Hickey and Mathis Wolter and Nicholas A Pudlo and Sho Kitamoto and Nicolas Terrapon and Arnaud Muller and Vincent B Young and Bernard Henrissat and Paul Wilmes and Thaddeus S Stappenbeck and Gabriel N{\'u}{\~n}ez and Eric C Martens},
  journal={Cell},
  year={2016},
  volume={167},
  pages={1339-1353.e21}
}
Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric… CONTINUE READING
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