A Dexamethasone Prodrug Reduces the Renal Macrophage Response and Provides Enhanced Resolution of Established Murine Lupus Nephritis

@inproceedings{Yuan2013ADP,
  title={A Dexamethasone Prodrug Reduces the Renal Macrophage Response and Provides Enhanced Resolution of Established Murine Lupus Nephritis },
  author={Fang Yuan and Dana E. Tabor and Richard K. Nelson and Hongjiang Yuan and Yijia Zhang and Jenny S Nuxoll and Kimberly K. Bynot{\'e} and Subodh Lele and Dong Wang and Karen A. Gould},
  booktitle={PloS one},
  year={2013}
}
We evaluated the ability of a macromolecular prodrug of dexamethasone (P-Dex) to treat lupus nephritis in (NZB × NZW)F1 mice. We also explored the mechanism underlying the anti-inflammatory effects of this prodrug. P-Dex eliminated albuminuria in most (NZB × NZW)F1 mice. Furthermore, P-Dex reduced the incidence of severe nephritis and extended lifespan in these mice. P-Dex treatment also prevented the development of lupus-associated hypertension and vasculitis. Although P-Dex did not reduce… CONTINUE READING
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