A Detailed Investigation on Conformation, Permeability and PK Properties of Two Related Cyclohexapeptides

@article{Lewis2014ADI,
  title={A Detailed Investigation on Conformation, Permeability and PK Properties of Two Related Cyclohexapeptides},
  author={Ian Lewis and Michael Schaefer and Trixie Wagner and Lukas Oberer and Emine Sager and Peter Wipfli and Thomas Vorherr},
  journal={International Journal of Peptide Research and Therapeutics},
  year={2014},
  volume={21},
  pages={205-221}
}
This contribution provides detailed insights regarding permeability properties of published cyclohexapeptides related to their conformation. The study includes data on oral bioavailability and PK parameters including application of a known enhancer. Interestingly, the latter did not show an effect, neither on the cyclic peptide exhibiting low oral uptake nor on the similar molecule showing a 30 % oral bioavailability in mice. These results are discussed in the context of exposed polar surface… CONTINUE READING
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