A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme

@inproceedings{Yu2015ADM,
  title={A Designed
Metalloenzyme Achieving the Catalytic Rate
of a Native Enzyme},
  author={Yang Yu and Chang Cui and Xiaohong Liu and Igor D. Petrik and Jiangyun Wang and Yi Lu},
  booktitle={Journal of the American Chemical Society},
  year={2015}
}
Terminal oxidases catalyze four-electron reduction of oxygen to water, and the energy harvested is utilized to drive the synthesis of adenosine triphosphate. While much effort has been made to design a catalyst mimicking the function of terminal oxidases, most biomimetic catalysts have much lower activity than native oxidases. Herein we report a designed oxidase in myoglobin with an O2 reduction rate (52 s(-1)) comparable to that of a native cytochrome (cyt) cbb3 oxidase (50 s(-1)) under… CONTINUE READING
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