A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

@article{Bashirova2001ADC,
  title={A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection},
  author={Arman Bashirova and Teunis B. H. Geijtenbeek and Gerard C F van Duijnhoven and Sandra J. van Vliet and Jeroen B. G. Eilering and Maureen P. Martin and Li Wu and T. D. Martin and Nicola K. Viebig and Percy A. Knolle and Vineet N Kewalramani and Yvette van Kooyk and Mary N. Carrington},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={193},
  pages={671 - 678}
}
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3–grabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T cells in trans has indicated a potentially important role for adhesion molecules in AIDS pathogenesis. A related molecule called DC-SIGNR exhibits 77% amino acid sequence identity with DC-SIGN. The DC-SIGN and DC-SIGNR genes map within a 30-kb region on chromosome 19p13.2-3. Their strong homology and… 

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