A Degradation Study of a Series of Chloromethyl and Diazomethyl Ketone Anti-leukemic Agents

@article{Kotchevar2002ADS,
  title={A Degradation Study of a Series of Chloromethyl and Diazomethyl Ketone Anti-leukemic Agents},
  author={A. T. Kotchevar and D. Perrey and F. Uckun},
  journal={Drug Development and Industrial Pharmacy},
  year={2002},
  volume={28},
  pages={143 - 149}
}
  • A. T. Kotchevar, D. Perrey, F. Uckun
  • Published 2002
  • Chemistry, Medicine
  • Drug Development and Industrial Pharmacy
  • ABSTRACT The chemical stability of a novel cysteine chloromethyl ketone derivative (HI-131) with anti-leukemic activity has been investigated in a microemulsion formulation. HI-131 degrades to two major products, most likely by undergoing oxidation and further reaction with another HI-131 molecule to form higher molecular weight oligomers of the original compound. The degradation kinetics of HI-131 have been studied as a function of pH, buffer composition, ionic strength, and temperature… CONTINUE READING

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    References

    SHOWING 1-6 OF 6 REFERENCES
    Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity.
    • 8
    Analytical Chemistry Handbook
    • 403
    Analytical Chemistry Handbook; McGrawHill
    • New York,
    • 1995
    Physical Pharmacy
    • 1993
    Physical Pharmacy, 4th ed.
    • Williams & Wilkins: Baltimore,
    • 1993