A Defined Zebrafish Line for High-Throughput Genetics and Genomics: NHGRI-1

Abstract

Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced to a depth of ∼50×. Within this strain… (More)
DOI: 10.1534/genetics.114.166769

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