A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis
@article{Bertholet2010ADT, title={A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis}, author={S. Bertholet and Gregory C. Ireton and D. Ordway and H. Windish and Samuel O. Pine and Maria Kahn and Tony Phan and I. Orme and T. Vedvick and S. Baldwin and R. Coler and S. Reed}, journal={Science Translational Medicine}, year={2010}, volume={2}, pages={53ra74 - 53ra74} }
A vaccine with a four-protein fusion peptide from Mycobacterium tuberculosis effectively boosts the current childhood TB vaccine and protects against drug-resistant TB. A Superior Shot for Tuberculosis Going to the doctor for routine “shots” is a dreaded childhood right of passage. The freedom from serious diseases—polio, smallpox, and diphtheria—clearly compensates for the pain. But one shot given in many countries (but not the United States)—bacillus Calmette-Guérin (BCG), a vaccine against… CONTINUE READING
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- The Journal of clinical investigation
- 2019
- 20
- Highly Influenced
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- Medicine
- Cold Spring Harbor perspectives in medicine
- 2014
- 112
- Highly Influenced
- PDF
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- 2019
- 2
- Highly Influenced
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- EBioMedicine
- 2017
- 12
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- Biology, Medicine
- Front. Immunol.
- 2017
- 66
- Highly Influenced
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- 2014
- 33
- Highly Influenced
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References
SHOWING 1-10 OF 39 REFERENCES
Novel prophylactic and therapeutic vaccine against tuberculosis.
- Medicine
- Vaccine
- 2009
- 42
- Highly Influential
Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis1
- Biology, Medicine
- The Journal of Immunology
- 2008
- 128
- PDF
A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis
- Sci. Transl. Med
- 2010
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.
- Medicine
- Vaccine
- 2010
- 195
Non-clinical efficacy and safety of HyVac4:IC31 vaccine administered in a BCG prime-boost regimen.
- Medicine
- Vaccine
- 2010
- 67
Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations.
- Chemistry, Medicine
- Colloids and surfaces. B, Biointerfaces
- 2010
- 98
Scien adjuvanted with IC 31 promotes strong and long - lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers
- Vaccine
- 2010
Zheng for their technical expertise; and L. Kunz for guinea pig tissue histology
- Submitted 22 March 2010 Accepted
- 2010
Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2009
- 145
- PDF