A Defined, Feeder-Free, Serum-Free System to Generate In Vitro Hematopoietic Progenitors and Differentiated Blood Cells from hESCs and hiPSCs

@inproceedings{Salvagiotto2011ADF,
  title={A Defined, Feeder-Free, Serum-Free System to Generate In Vitro Hematopoietic Progenitors and Differentiated Blood Cells from hESCs and hiPSCs},
  author={Giorgia Salvagiotto and Sarah Burton and Christine A. Daigh and D. Gnana Rajesh and Igor I Slukvin and Nicholas J. Seay},
  booktitle={PloS one},
  year={2011}
}
Human ESC and iPSC are an attractive source of cells of high quantity and purity to be used to elucidate early human development processes, for drug discovery, and in clinical cell therapy applications. To efficiently differentiate pluripotent cells into a pure population of hematopoietic progenitors we have developed a new 2-dimensional, defined and highly efficient protocol that avoids the use of feeder cells, serum or embryoid body formation. Here we showed that a single matrix protein in… CONTINUE READING

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