A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of Ito and Confers Susceptibility to Ventricular Tachycardia

@article{Kuo2001ADI,
  title={A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of Ito and Confers Susceptibility to Ventricular Tachycardia},
  author={Hai-Chien Kuo and Ching Fung Cheng and Robert S B Clark and Jim J.-C. Lin and Jenny L.-C. Lin and Masahiko Hoshijima and V{\^a}n T.B. Nguy{\^e}{\~n}-Tr{\^a}n and Yusu Gu and Yasuhiro Ikeda and P H Chu and John Ross and Wayne R Giles and Kenneth R. Chien},
  journal={Cell},
  year={2001},
  volume={107},
  pages={801-813}
}
KChIP2, a gene encoding three auxiliary subunits of Kv4.2 and Kv4.3, is preferentially expressed in the adult heart, and its expression is downregulated in cardiac hypertrophy. Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2(-/-) mice are highly susceptible to the induction of cardiac arrhythmias. Single-cell analysis revealed a substrate for arrhythmogenesis, including a complete… CONTINUE READING
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