A Deep Sequencing Approach to Uncover the miRNOME in the Human Heart

@inproceedings{Leptidis2013ADS,
  title={A Deep Sequencing Approach to Uncover the miRNOME in the Human Heart},
  author={Stefanos Leptidis and Hamid el Azzouzi and Sjoukje I. Lok and Roel de Weger and Serv Olieslagers and Natasja Kisters and Gustavo J. J. Silva and Stephane Heymans and Edwin Cuppen and Eugene Berezikov and Leon J. de Windt and Paula da Costa Martins},
  booktitle={PloS one},
  year={2013}
}
MicroRNAs (miRNAs) are a class of non-coding RNAs of ∼22 nucleotides in length, and constitute a novel class of gene regulators by imperfect base-pairing to the 3'UTR of protein encoding messenger RNAs. Growing evidence indicates that miRNAs are implicated in several pathological processes in myocardial disease. The past years, we have witnessed several profiling attempts using high-density oligonucleotide array-based approaches to identify the complete miRNA content (miRNOME) in the healthy… CONTINUE READING