A Decapeptide from Durum Wheat Prevents Celiac Peripheral Blood Lymphocytes from Activation by Gliadin Peptides

@article{Silano2007ADF,
  title={A Decapeptide from Durum Wheat Prevents Celiac Peripheral Blood Lymphocytes from Activation by Gliadin Peptides},
  author={Marco Silano and Rita Di Benedetto and Antonello Trecca and Gioacchino Arrabito and Fabiana Leonardi and Massimo De Vincenzi},
  journal={Pediatric Research},
  year={2007},
  volume={61},
  pages={67-71}
}
Identifying antagonist peptides able to inhibit the abnormal immune response triggered by gliadin peptides in celiac disease (CD) is an alternative therapeutic strategy for CD. The aim of this study was to evaluate the antagonist effect of 10mer, a decapeptide (sequence QQPQDAVQPF) from alcohol-soluble protein fraction of durum wheat, assessing its ability to prevent celiac peripheral blood lymphocytes from activation by gliadin peptides. Peripheral blood mononuclear cells (PBMC) were obtained… CONTINUE READING

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