A comparative study of Chinese herbal medicine Fukang Pian with clonidine hydrochloride on opiate withdrawal symptoms
- S Guo, ZN Liang, YD Wang, GC Hu, YM Wu, MS. Huang
- Chin Bull Drug Depend 4(4):210-216
Background and objectives: Traditional Chinese medicine (TCM) has been used to treat drug addiction for more than 160 years, and has accumulated valuable experience in the detoxification and rehabilitation of patients. The aims of this project were (1) to establish a computerised, bilingual (Chinese–English) database on TCM treatment for drug addiction, (2) to analyse the literature features published in this field, and (3) to identify the commonly used Chinese herbs as well as toxic herbs for drug addiction. Methods: (1) Paper collection: related papers were collected through electronic databases and hand-searched materials. (2) Data computerisation: the Microsoft Access programme and Delphi language were used as the major data management systems. (3) Paper analysis: annual publications from 1989 to 2003 were classified and calculated. (4) Herbal analysis: the frequency of commonly used herbs and herbal function categories were analysed. Results: (1) A special bilingual database (CDR) that contained 340 professional literatures including 85 patent files on TCM treatment for drug addiction was established, in which more than 90% of the publications originated from Mainland China; (2) besides the translation of the titles, author (patentee) names, institutions, sources, abstracts and keywords, the database also uniquely included the translations of all herbal names (Chinese names, Chinese pinyin, English names or Latino botanical names) in published papers; (3) the literature classification showed an increase of publications in this field over the past decade, and, the number of papers on clinical and laboratory researches, in particular, had a significant increase; and (4) five functional categorisations of Chinese herbs and ten most frequently used Chinese herbs as well as three toxic herbs were identified from more than 200 herbs reported in 150 original research articles and 85 patent literatures. Part 5: Advances in drug abuse research 387 Conclusion: It was the first time that the published data on TCM in treatment of drug addiction had been systematically analysed by using a new database, and the results are valuable for further laboratory and clinical studies to obtain more direct evidence.