A Darwinian-evolutionary concept of age-related diseases

@article{Wick2003ADC,
  title={A Darwinian-evolutionary concept of age-related diseases},
  author={Georg Wick and Peter Berger and Pidder Jansen-D{\"u}rr and Beatrix Grubeck‐Loebenstein},
  journal={Experimental Gerontology},
  year={2003},
  volume={38},
  pages={13-25}
}
Humans and animals are structurally designed as a compromise to guarantee optimal survival until the time of reproduction based on natural selection that is effective until that age. Modern conditions of life including improvement of hygiene, preventive and curative medicine as well as socio-economic and political developments have led to an increase of the mean life expectancy that allows ever larger proportions of the population to reach an age that is far beyond that of the reproductive… Expand
Are Age-Associated Diseases an Integral Part of Aging?
TLDR
This chapter evaluates the relationship between aging and age-associated diseases and proposes that those genes that increase evolutionary fitness in early life will be selected for, even if they have catastrophic deleterious effects in late life. Expand
‘Evolutionary medicine’ perspectives on Alzheimer’s Disease: Review and new directions
  • Molly Fox
  • Medicine, Biology
  • Ageing Research Reviews
  • 2018
TLDR
8 distinct hypotheses based on the concepts of novel extension of the lifespan; lack of selective pressure during the post-reproductive phase; antagonistic pleiotropy; rapid brain evolution; delayed neuropathy by selection for grandmothering; novel alleles selected to delay neuropathy; by-product of selection against cardiovascular disease; and thrifty genotype are summarized. Expand
Biology of longevity: role of the innate immune system.
TLDR
The data coming from the long-lived male population under study show that genetic polymorphisms responsible for a low inflammatory response might result in an increased chance of long lifespan in an environment with a reduced pathogen burden. Expand
The Evolutionary Theories of Aging Revisited – A Mini-Review
TLDR
This short review portrays the evolutionary theories of aging in the light of the existing discoveries from genomic and molecular genetic studies on aging and longevity in centenarians as well as the proposals for future research in biogerontology. Expand
Why we age – a new evolutionary view
TLDR
A new evolutionary theory of aging is introduced, which suggests that aging is the result of imperfections in cell turnover in organisms, and the trade-off in reversible damage plays a role in basal metabolic rate. Expand
Epistemological and moral lessons from the history of neurodegenerative diseases
TLDR
A genetic-evolutionary approach to disease proves to be more compatible with prevention strategies through social and cultural intervention than traditional medical-scientific philosophy which focuses mainly on treatments addressing the proximate etiological and pathogenetic mechanisms. Expand
Atherosclerosis as a paradigmatic disease of the elderly: role of the immune system.
TLDR
The concept that atherosclerosis is a good example of pleotropic antagonism is proposed, and it is postulated that age-dependent diseases are the price the authors pay for genetic traits established by natural selection to assure maximum survival until the age of reproduction. Expand
Accelerated immunosenescence in preindustrial twin mothers.
  • S. Helle, V. Lummaa, J. Jokela
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
Examination of reproductive effort in women born in preindustrial Finland between 1702 and 1859 found that mothers delivering twins had reduced postreproductive survival after age 65, and the mechanism mediating this cost might have been accelerated immunosenescence. Expand
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
TLDR
Low responder genotypes involved in regulation of innate defence mechanisms, might better control inflammatory responses and age-related disease development, resulting in an increased chance of long life survival in a "permissive" environment with reduced pathogen load, medical care and increased quality of life. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 100 REFERENCES
Diseases of aging.
TLDR
The general thread of this presentation relies on the concept of an evolutionary-Darwinian view of the development of age-related diseases, which states that the authors may have to "pay" for genetic traits that play a beneficial role earlier in life by the later development of diseases. Expand
Stem cells and aging: expanding the possibilities
TLDR
The remarkable plasticity of stem cells suggests that endogenous or transplanted stem cells can be 'tweaked' in ways that will allow them to replace lost or dysfunctional cell populations in diseases ranging from neurodegenerative and hematopoietic disorders to diabetes and cardiovascular disease. Expand
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again.
TLDR
Current data regarding developmental regulation of telomerase in humans, mice, chickens and flowering plants is presented and differentiation, quiescence and telomere activity regulation will be addressed in three human representative tissue systems; blood, skin, and intestine. Expand
The role of cellular senescence in skin aging.
  • J. Campisi
  • Biology, Medicine
  • The journal of investigative dermatology. Symposium proceedings
  • 1998
TLDR
Senescent keratinocytes and fibroblasts appear to accumulate with age in human skin, and they express genes that have long-range, pleiotropic effects - degradative enzymes, growth factors, and inflammatory cytokines, which might compromise skin function and integrity. Expand
Ageing and cancer: the telomere and telomerase connection.
TLDR
Telomerase-induced telomere length manipulations may have utility for tissue engineering and for dissecting the molecular mechanisms underlying genetic diseases including cancer. Expand
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
TLDR
It is shown that senescent human fibroblasts stimulate premalignant and malignant, but not normal, epithelial cells to proliferate in culture and form tumors in mice, suggesting it is an example of evolutionary antagonistic pleiotropy. Expand
Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
Human ageing is characterized by a progressive loss of physiological functions, increased tissue damage and defects in various tissue renewal systems. Age-related decreases of the cellularExpand
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
TLDR
It is shown that vaccination with Aβ protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease and may prevent and, possibly, treat Alzheimer's dementia. Expand
Is atherosclerosis an autoimmune disease
TLDR
This Viewpoint postulates that atherosclerosis is initiated by an (auto)immune-mediated reaction, and that a high blood cholesterol level is only one — albeit the most important — additional risk factor. Expand
The possible role of the immune system in Alzheimer’s disease
TLDR
AD is a good example how an immune response initially aiming at maintaining the integrity of the body may fail and consequently lead to tissue destruction and neuronal loss in the brain, as described above. Expand
...
1
2
3
4
5
...