A Darwinian approach to Huntington's disease: subtle health benefits of a neurological disorder.

@article{Eskenazi2007ADA,
  title={A Darwinian approach to Huntington's disease: subtle health benefits of a neurological disorder.},
  author={Benjamin R Eskenazi and Noah S Wilson-Rich and Philip T. Starks},
  journal={Medical hypotheses},
  year={2007},
  volume={69 6},
  pages={
          1183-9
        }
}
Huntington's disease (HD) is a neurodegenerative disorder that, unlike most autosomal dominant disorders, is not being selected against. One explanation for the maintenance of the mutant HD allele is that it is transparent to natural selection because disease symptoms typically occur subsequent to an individual's peak reproductive years. While true, this observation does not explain the population-level increase in HD. The increase in HD is at least partly the result of enhanced fitness: HD… CONTINUE READING
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