A DPYD variant (Y186C) in individuals of African ancestry associated with reduced DPD enzyme activity

@inproceedings{Offer2013ADV,
  title={A DPYD variant (Y186C) in individuals of African ancestry associated with reduced DPD enzyme activity},
  author={Steven M. Offer and Adam M. Lee and Lori Kay Mattison and Croix C. Fossum and Natalie J. Wegner and Robert B. Diasio},
  booktitle={Clinical pharmacology and therapeutics},
  year={2013}
}
5-Fluorouracil (5-FU) is used to treat many aggressive cancers, such as those of the colon, breast, and head and neck. The responses to 5-FU, with respect to both toxicity and efficacy, vary among racial groups, potentially because of variability in the activity levels of the enzyme dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene). In this study, the genetic associations between DPYD variations and circulating mononuclear-cell DPD enzyme activity were evaluated in 94 African… CONTINUE READING