A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.

@article{Farrell2012ADP,
  title={A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.},
  author={Andrew D. H. Farrell and Sivasakthivel Thirugnanam and Alexander Lorestani and Jeffrey D. Dvorin and Keith P Eidell and David J. P. Ferguson and Brooke R Anderson-White and Manoj Duraisingh and Gabor T. Marth and Marc-Jan Gubbels},
  journal={Science},
  year={2012},
  volume={335 6065},
  pages={218-21}
}
Exocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis of toxoplasmosis and malaria. DOC2 proteins recruit the membrane fusion machinery required for exocytosis in a Ca(2+)-dependent fashion. Here, the phenotype of a Toxoplasma gondii conditional mutant impaired in host cell invasion and egress was pinpointed to a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion proteins. Whole-genome sequencing… CONTINUE READING
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Biochim

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