A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth.

@article{Holmgren2006ADV,
  title={A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth.},
  author={Lars Holmgren and Elena Ambrosino and Olivier Birot and Carl Tullus and Niina Veitonm{\"a}ki and Tetyana Levchenko and L Carlson and Piero Musiani and Manuela Iezzi and Claudia Curcio and Guido Forni and Federica Cavallo and Rolf Kiessling},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 24},
  pages={9208-13}
}
Endogenous angiogenesis inhibitors have shown promise in preclinical trials, but clinical use has been hindered by low half-life in circulation and high production costs. Here, we describe a strategy that targets the angiostatin receptor angiomotin (Amot) by DNA vaccination. The vaccination procedure generated antibodies that detected Amot on the… CONTINUE READING