A DNA vaccine constructed with human papillomavirus type 16 (HPV16) E7 and E6 genes induced specific immune responses.

@article{Yan2007ADV,
  title={A DNA vaccine constructed with human papillomavirus type 16 (HPV16) E7 and E6 genes induced specific immune responses.},
  author={Qin Yan and Y K Cheung and Samuel Cheng and X Wang and Meng Shi and Mei-Haob Hu and Xie Yong},
  journal={Gynecologic oncology},
  year={2007},
  volume={104 1},
  pages={199-206}
}
OBJECTIVE Cervical cancer is found highly associated with human papillomaviruses type 16 (HPV16). HPV16 E6 and E7 oncogenes are important transforming genes which have become the main focus of anti-cervical cancer therapy. In this study, a recombinant DNA vaccine candidate, termed HPV16-DNA-E6E7, constructed with HPV16 E7 and E6 genes was generated and used to against HPV16-induced tumors. METHODS We inserted an E7 DNA fragment into E6 gene to produce a recombinant gene (E6E7-DNA). The E6E7… CONTINUE READING