A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma

@article{Lan2006ADV,
  title={A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma},
  author={Ying-hua Lan and Yong-guo Li and Zeng-wei Liang and Min Chen and Mingli Peng and Li Tang and Huai-dong Hu and Hongkai Ren},
  journal={Cancer Immunology, Immunotherapy},
  year={2006},
  volume={56},
  pages={1009-1016}
}
Alpha-Fetoprotein (AFP) is produced principally in fetal liver, gastrointestinal tract and the yolk sac which is temporarily present during embryonic development. AFP is overexpressed in the majority of Hepatocellular Carcinoma (HCC) and thus offers an attractive target for immunotherapy against this neoplasm. Here, we report that anti-HCC effects were achieved in a therapeutic setting with a DNA vaccine encoding mouse AFP and co-expressing Heat Shock Protein 70 (HSP70) gene. We also… CONTINUE READING
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