A DNA tweezer-actuated enzyme nanoreactor.

@article{Liu2013ADT,
  title={A DNA tweezer-actuated enzyme nanoreactor.},
  author={Minghui Liu and Jinglin Fu and Christian Hejesen and Yuhe Renee Yang and Neal W. Woodbury and Kurt Vesterager Gothelf and Yan Liu and Hao Yan},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2127}
}
The functions of regulatory enzymes are essential to modulating cellular pathways. Here we report a tweezer-like DNA nanodevice to actuate the activity of an enzyme/cofactor pair. A dehydrogenase and NAD(+) cofactor are attached to different arms of the DNA tweezer structure and actuation of enzymatic function is achieved by switching the tweezers between open and closed states. The enzyme/cofactor pair is spatially separated in the open state with inhibited enzyme function, whereas in the… CONTINUE READING
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