A DNA tweezer-actuated enzyme nanoreactor.

  title={A DNA tweezer-actuated enzyme nanoreactor.},
  author={Minghui Liu and Jinglin Fu and Christian Hejesen and Yuhe Renee Yang and Neal W. Woodbury and Kurt Vesterager Gothelf and Yan Liu and Hao Yan},
  journal={Nature communications},
The functions of regulatory enzymes are essential to modulating cellular pathways. Here we report a tweezer-like DNA nanodevice to actuate the activity of an enzyme/cofactor pair. A dehydrogenase and NAD(+) cofactor are attached to different arms of the DNA tweezer structure and actuation of enzymatic function is achieved by switching the tweezers between open and closed states. The enzyme/cofactor pair is spatially separated in the open state with inhibited enzyme function, whereas in the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 35 extracted citations


Publications referenced by this paper.
Showing 1-10 of 43 references

Smart materials : a review of recent developments

  • R. Bogue
  • Assembly Automation
  • 2012

a review of recent developments

  • Bogue, R. Smart materials
  • Assembly Automation 21, 3–7
  • 2012

DNA-based switchable devices and materials

  • D. Liu, E. Cheng, Z. Yang
  • NPG Asia Mater
  • 2011

Similar Papers

Loading similar papers…