A DNA polymerase beta mutant from colon cancer cells induces mutations.

@article{Lang2004ADP,
  title={A DNA polymerase beta mutant from colon cancer cells induces mutations.},
  author={Tieming Lang and Mausumi Maitra and Daniela Starcevic and Shu-xia Li and Joann Balazs Sweasy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 16},
  pages={6074-9}
}
Previous investigations have shown that approximately 35% of the 90 tumors analyzed to date contain mutations within the DNA polymerasebeta (pol beta) gene. The existence of pol beta mutations in a substantial fraction of human tumors studied suggests a link between DNA pol beta and cancer. A DNA pol beta variant, in which Lys-289 has been altered to Met, was identified previously in a colorectal carcinoma. The K289M protein was expressed in mouse L cells containing the lambda cII mutational… CONTINUE READING
24 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…