A DNA enzyme that cleaves RNA.

  title={A DNA enzyme that cleaves RNA.},
  author={R. Breaker and G. F. Joyce},
  journal={Chemistry & biology},
  volume={1 4},
  • R. Breaker, G. F. Joyce
  • Published 1994
  • Biology, Medicine
  • Chemistry & biology
  • BACKGROUND Several types of RNA enzymes (ribozymes) have been identified in biological systems and generated in the laboratory. Considering the variety of known RNA enzymes and the similarity of DNA and RNA, it is reasonable to imagine that DNA might be able to function as an enzyme as well. No such DNA enzyme has been found in nature, however. We set out to identify a metal-dependent DNA enzyme using in vitro selection methodology. RESULTS Beginning with a population of 10(14) DNAs… CONTINUE READING
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